Tetrahydrofuran → HCID 178500108, compound

HRID 1555933Notes

Reaction equation

HRID 1555933 reaction equation
[Br:1][c:2]1[cH:3][n:4]([CH3:27])[c:5]2[c:6](-[c:11]3[n:12][o:13][c:14](-[c:16]4[cH:17][c:18]([Cl:26])[c:19]([O:22][CH:23]([CH3:24])[CH3:25])[cH:20][cH:21]4)[n:15]3)[cH:7][cH:8][cH:9][c:10]12.[Br:47][Zn:48][CH2:49][CH:50]([C:51](=[O:52])[O:53][CH3:54])[CH3:55].[C:41](=[O:42])([O-:43])[O-:44].[CH2:56]1[O:57][CH2:58][CH2:59][CH2:60]1.[CH3:28][C:29]([P:30]([C:31]([CH3:32])([CH3:33])[CH3:34])[C:35]([CH3:36])([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Cs+:45].[Cs+:46].[O:63]=[C:64]([CH:65]=[CH:66][c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1)[CH:73]=[CH:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1.[O:81]=[C:82]([CH:83]=[CH:84][c:85]1[cH:86][cH:87][cH:88][cH:89][cH:90]1)[CH:91]=[CH:92][c:93]1[cH:94][cH:95][cH:96][cH:97][cH:98]1.[O:99]=[C:100]([CH:101]=[CH:102][c:103]1[cH:104][cH:105][cH:106][cH:107][cH:108]1)[CH:109]=[CH:110][c:111]1[cH:112][cH:113][cH:114][cH:115][cH:116]1.[Pd:61].[Pd:62]>>[c:2]1([CH2:49][CH:50]([C:51](=[O:52])[O:53][CH3:54])[CH3:55])[cH:3][n:4]([CH3:27])[c:5]2[c:6](-[c:11]3[n:12][o:13][c:14](-[c:16]4[cH:17][c:18]([Cl:26])[c:19]([O:22][CH:23]([CH3:24])[CH3:25])[cH:20][cH:21]4)[n:15]3)[cH:7][cH:8][cH:9][c:10]12

Participants

9

Reactant 8

HCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 23938Palladium2×HCID 83681Tris(1,1-dimethylethyl)phosphineHCID 95417Dibenzylidene acetone3×HCID 104967Cesium cation2×HCID 591461473-bromo-7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-methyl-1H-indoleHCID 178500473HCID 178500473, compound

Product 1

HCID 178500108HCID 178500108, compound

Sources & evidence

ORD record
ord-458385155789474fbdfc51e0b41569f3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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