Tetrahydrofuran → 2-(Aminomethyl)-1-[4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methylbutan-1-one
Reaction equation
[CH2:68]([N+:69]([CH2:70][CH2:71][CH2:72][CH3:73])([CH2:74][CH2:75][CH2:76][CH3:77])[CH2:78][CH2:79][CH2:80][CH3:81])[CH2:82][CH2:83][CH3:84].[CH2:91]1[O:92][CH2:93][CH2:94][CH2:95]1.[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:31][C:32]([NH:7][CH2:8][CH:9]([CH:10]([CH3:11])[CH3:12])[C:13](=[O:14])[N:15]1[CH2:16][C:17]([CH3:29])([CH3:30])[C:18]([OH:21])([c:22]2[cH:23][cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[CH2:19][CH2:20]1)=[O:33].[CH3:85][CH2:86][O:87][C:88]([CH3:89])=[O:90].[Cl:34][c:35]1[cH:36][cH:37][c:38]([C:39]([NH:40][CH:41]([CH:42]([CH3:43])[CH3:44])[CH2:45][C:46]([N:47]2[CH2:48][CH2:49][C:50]([c:51]3[cH:52][cH:53][c:54]([Cl:55])[cH:56][cH:57]3)([OH:58])[C:59]([CH3:60])([CH3:61])[CH2:62]2)=[O:63])=[O:64])[cH:65][cH:66]1.[F-:67]>>[NH2:7][CH2:8][CH:9]([CH:10]([CH3:11])[CH3:12])[C:13](=[O:14])[N:15]1[CH2:16][C:17]([CH3:29])([CH3:30])[C:18]([OH:21])([c:22]2[cH:23][cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[CH2:19][CH2:20]1Participants
7
Sources & evidence
- ORD record
- ord-894c35679cec401085e7dc206f2916f9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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