Tetrahydrofuran → 2,5-dimethyl-N-(4-methylphenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-6-amine

HRID 1557402Notes

Reaction equation

HRID 1557402 reaction equation
[Al+3:29].[CH2:1]([O:2][C:4](=[O:3])[N:6]1[CH2:7][c:8]2[c:9]([n:10]([CH3:25])[c:11]3[c:12]([NH:17][c:18]4[cH:19][cH:20][c:21]([CH3:24])[cH:22][cH:23]4)[cH:13][cH:14][cH:15][c:16]23)[CH2:26][CH2:27]1)[CH3:5].[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[H-:28].[H-:31].[H-:32].[H-:33].[Li+:30]>>[CH3:4][N:6]1[CH2:7][c:8]2[c:9]([n:10]([CH3:25])[c:11]3[c:12]([NH:17][c:18]4[cH:19][cH:20][c:21]([CH3:24])[cH:22][cH:23]4)[cH:13][cH:14][cH:15][c:16]23)[CH2:26][CH2:27]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 68816344Ethyl-5-methyl-6-(4-toluidino)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

Product 1

HCID 688158882,5-dimethyl-N-(4-methylphenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-6-amine

Sources & evidence

ORD record
ord-22df802e8a884b84af3e86c21e1f5743
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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