Acetate → t-Butyl 2-(1,3-thiazol-2-yl)-1H-pyrrole-1-carboxylate

HRID 1557884Notes

Reaction equation

HRID 1557884 reaction equation
[Br:16][c:17]1[s:18][cH:19][cH:20][n:21]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[c:9]([B:13]([OH:14])[OH:15])[cH:10][cH:11][cH:12]1.[C:41](=[O:42])([O-:43])[O-:44].[CH3:47][O:48][CH2:49][CH2:50][O:51][CH3:52].[CH3:63][CH2:64][O:65][C:66](=[O:67])[CH3:68].[K+:45].[K+:46].[O-:55][C:56]([CH3:57])=[O:58].[O-:59][C:60]([CH3:61])=[O:62].[OH2:53].[Pd+2:54].[c:22]1([P:23]([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:36][cH:37][cH:38][cH:39][cH:40]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[c:9](-[c:17]2[s:18][cH:19][cH:20][n:21]2)[cH:10][cH:11][cH:12]1

Participants

11

Reactant 10

HCID 175Acetate2×HCID 813Potassium Cation2×HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 8857Ethyl AcetateHCID 11776TriphenylphosphineHCID 19660Carbonate IonHCID 764302-BromothiazoleHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27343211-(tert-Butoxycarbonyl)-2-pyrroleboronic Acid

Product 1

HCID 66681244t-Butyl 2-(1,3-thiazol-2-yl)-1H-pyrrole-1-carboxylate

Sources & evidence

ORD record
ord-b2b79b6711d14b6a8bbefc32bc391205
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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