Methanol → Methyl 4-{5-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]pyridin-2-yl}piperazine-1-carboxylate

HRID 1558259Notes

Reaction equation

HRID 1558259 reaction equation
[CH3:1][N:2]1[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1.[CH3:54][C:55]#[N:56].[CH3:57][OH:58].[Cl:49][C:50](=[O:51])[O:52][CH3:53].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48].[N:8]1([c:14]2[cH:15][cH:16][c:17](-[c:20]3[cH:21][n:22][c:23]4[n:24]([cH:25]3)[c:26]([C:29]3([c:32]5[cH:33][c:34]6[cH:35][cH:36][cH:37][n:38][c:39]6[cH:40][cH:41]5)[CH2:30][CH2:31]3)[cH:27][n:28]4)[cH:18][n:19]2)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1>>[N:8]1([c:14]2[cH:15][cH:16][c:17](-[c:20]3[cH:21][n:22][c:23]4[n:24]([cH:25]3)[c:26]([C:29]3([c:32]5[cH:33][c:34]6[cH:35][cH:36][cH:37][n:38][c:39]6[cH:40][cH:41]5)[CH2:30][CH2:31]3)[cH:27][n:28]4)[cH:18][n:19]2)[CH2:9][CH2:10][N:11]([C:50](=[O:51])[O:52][CH3:53])[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 887MethanolHCID 6342AcetonitrileHCID 6422Trifluoroacetic acidHCID 6586Methyl chloroformateHCID 79724-MethylmorpholineHCID 672246286-{1-[6-(6-Piperazin-1-ylpyridin-3-yl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline

Product 1

HCID 25144531Methyl 4-{5-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]pyridin-2-yl}piperazine-1-carboxylate

Sources & evidence

ORD record
ord-69e68abe93ab423fb109e3a54b368245
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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