Tetrahydrofuran → N-[4-[[2-(Aminocarbonyl)-4-pyridinyl]oxy]-2,5-difluorophenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

HRID 1559009Notes

Reaction equation

HRID 1559009 reaction equation
[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[F:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9](=[O:10])[C:11]2([C:14](=[O:15])[OH:16])[CH2:12][CH2:13]2)[cH:6][cH:7]1.[NH2:28][c:29]1[cH:30][c:31]([F:46])[c:32]([O:33][c:34]2[cH:35][c:36]([C:40](=[O:41])[NH2:42])[n:37][cH:38][cH:39]2)[cH:43][c:44]1[F:45].[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1.[S:24]([Cl:25])([Cl:26])=[O:27]>>[F:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9](=[O:10])[C:11]2([C:14](=[O:16])[NH:28][c:29]3[cH:30][c:31]([F:46])[c:32]([O:33][c:34]4[cH:35][c:36]([C:40](=[O:41])[NH2:42])[n:37][cH:38][cH:39]4)[cH:43][c:44]3[F:45])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 210815301-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic AcidHCID 247886284-(4-Amino-2,5-difluorophenoxy)pyridine-2-carboxamide

Product 1

HCID 59597002N-[4-[[2-(Aminocarbonyl)-4-pyridinyl]oxy]-2,5-difluorophenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Sources & evidence

ORD record
ord-c47a0971ac124453bced64809492d396
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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