Hydrochloric Acid → 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinol

HRID 1559402Notes

Reaction equation

HRID 1559402 reaction equation
[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[O:9][c:10]1[c:11]([O:29][CH3:30])[cH:12][c:13]2[c:14]([NH:20][c:21]3[c:22]([F:28])[cH:23][c:24]([Br:27])[cH:25][cH:26]3)[n:15][cH:16][n:17][c:18]2[cH:19]1.[ClH:1].[F:31][C:32]([F:33])([F:34])[C:35]([OH:36])=[O:37]>>[OH:9][c:10]1[c:11]([O:29][CH3:30])[cH:12][c:13]2[c:14]([NH:20][c:21]3[c:22]([F:28])[cH:23][c:24]([Br:27])[cH:25][cH:26]3)[n:15][cH:16][n:17][c:18]2[cH:19]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 106235847-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

Product 1

HCID 1355038524-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinol

Sources & evidence

ORD record
ord-2d9904f8bc5b4153b0f831670073169d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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