Sodium ion → Tert-butyl 3-[(5-chlorothiophene-2-carbonyl)amino]-4-(2,2-difluoroethoxy)pyrrolidine-1-carboxylate

HRID 1559442Notes

Reaction equation

HRID 1559442 reaction equation
[C:3]([CH3:4])([CH3:5])([CH3:6])[O:7][C:8](=[O:9])[N:10]1[CH2:11][CH:12]([NH:16][C:17](=[O:18])[c:19]2[s:20][c:21]([Cl:24])[cH:22][cH:23]2)[CH:13]([OH:15])[CH2:14]1.[CH3:42][CH2:43][O:44][C:45]([CH3:46])=[O:47].[F:25][C:26]([F:27])([F:28])[S:29]([O:30][CH2:31][CH:32]([F:33])[F:34])(=[O:35])=[O:36].[H-:2].[Na+:1].[O:37]=[CH:38][N:39]([CH3:40])[CH3:41]>>[C:3]([CH3:4])([CH3:5])([CH3:6])[O:7][C:8](=[O:9])[N:10]1[CH2:11][CH:12]([NH:16][C:17](=[O:18])[c:19]2[s:20][c:21]([Cl:24])[cH:22][cH:23]2)[CH:13]([O:15][CH2:31][CH:32]([F:33])[F:34])[CH2:14]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 166653HydrideHCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 74835283tert. Butyl (3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-pyrrolidine-1-carboxylate

Product 1

HCID 74835284Tert-butyl 3-[(5-chlorothiophene-2-carbonyl)amino]-4-(2,2-difluoroethoxy)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-749748109635484faed7d233488ab37d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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