Chloride → [5-(3-chloro-benzylamino)-2-methyl-2H-pyrazol-3-yl]-(5-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol
Reaction equation
[CH:23]([Mg+:24])([CH3:25])[CH3:26].[Cl-:22].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([Si:12]([CH:13]([CH3:14])[CH3:15])([CH:16]([CH3:17])[CH3:18])[CH:19]([CH3:20])[CH3:21])[cH:9][c:10]2[I:11].[Cl:27][c:28]1[cH:29][c:30]([CH2:31][NH:32][c:33]2[cH:34][c:35]([CH:39]=[O:40])[n:36]([CH3:38])[n:37]2)[cH:41][cH:42][cH:43]1.[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([Si:12]([CH:13]([CH3:14])[CH3:15])([CH:16]([CH3:17])[CH3:18])[CH:19]([CH3:20])[CH3:21])[cH:9][c:10]2[CH:39]([c:35]1[cH:34][c:33]([NH:32][CH2:31][c:30]2[cH:29][c:28]([Cl:27])[cH:43][cH:42][cH:41]2)[n:37][n:36]1[CH3:38])[OH:40]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-4fe00470e3f1498890a5137fbfcf8f91
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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