Tetrahydrofuran → N-BOC-4-(phenylethynyl)piperidine

HRID 1562000Notes

Reaction equation

HRID 1562000 reaction equation
[C:1](#[CH:2])[CH:3]1[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1.[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[Cu:28]([I:29])[I:30].[I:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>>[C:1](#[C:2][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[CH:3]1[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11575IodobenzeneHCID 83717Copper iodideHCID 15550481tert-Butyl 4-ethynylpiperidine-1-carboxylate

Product 1

HCID 17986993N-BOC-4-(phenylethynyl)piperidine

Sources & evidence

ORD record
ord-fc7fd6b9050944bf9e94c726f12c5ca7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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