Ethanol → 6-Fluoro-5-(5-methoxy-1-benzofuran-2-yl)pyridin-2-amine
Reaction equation
[BH:1]([OH:2])[OH:3].[Br:15][c:16]1[cH:17][cH:18][c:19]([NH2:23])[n:20][c:21]1[F:22].[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[CH3:31][CH2:32][OH:33].[CH3:4][O:5][c:6]1[cH:7][cH:8][c:9]2[c:10]([cH:11][cH:12][o:13]2)[cH:14]1.[Pd:34]([Cl:35])[Cl:36].[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1.[c:56]1([P:57]([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[cH:70][cH:71][cH:72][cH:73][cH:74]1>>[CH3:4][O:5][c:6]1[cH:7][cH:8][c:9]2[c:10]([cH:11][c:12](-[c:16]3[cH:17][cH:18][c:19]([NH2:23])[n:20][c:21]3[F:22])[o:13]2)[cH:14]1Participants
8
Sources & evidence
- ORD record
- ord-2dce6cd7106546ff8cdf88d9e37a7e6a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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