Acetate → tert-Butyl 4-(4-cyclopropyl-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

HRID 1562647Notes

Reaction equation

HRID 1562647 reaction equation
[Br:1][c:2]1[n:3][c:4]([CH:16]2[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]2)[n:5]([CH2:7][CH2:8][O:9][CH:10]2[O:11][CH2:12][CH2:13][CH2:14][CH2:15]2)[cH:6]1.[C:70]([O-:71])(=[O:72])[CH3:73].[C:75]([O-:76])(=[O:77])[CH3:78].[CH3:62][c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1.[CH:29]1([B:32]([OH:33])[OH:34])[CH2:30][CH2:31]1.[CH:35]1([P:36]([CH:37]2[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]2)[CH:43]2[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]2)[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53]1.[K+:59].[K+:60].[K+:61].[OH2:69].[P:54]([O-:55])([O-:56])([O-:57])=[O:58].[Pd+2:74]>>[c:2]1([CH:29]2[CH2:30][CH2:31]2)[n:3][c:4]([CH:16]2[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]2)[n:5]([CH2:7][CH2:8][O:9][CH:10]2[O:11][CH2:12][CH2:13][CH2:14][CH2:15]2)[cH:6]1

Participants

10

Reactant 9

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 1140TolueneHCID 75806TricyclohexylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2760897Cyclopropylboronic acidHCID 67265112tert-Butyl 4-(4-bromo-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Product 1

HCID 67968740tert-Butyl 4-(4-cyclopropyl-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7a0a0dbc7dcd49c58edc71e6b7007859
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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