Tetrahydrofuran → 4-[1-(3-Bromo-5-methoxymethyl-thiophen-2-yl)-methanoyl]-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Br:9][c:10]1[cH:11][c:12]([CH2:15][O:16][CH3:17])[s:13][cH:14]1.[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH2:26][CH2:27][CH:28]([C:31]([N:32]([O:33][CH3:34])[CH3:35])=[O:36])[CH2:29][CH2:30]1.[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Li+:8].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[Br:9][c:10]1[cH:11][c:12]([CH2:15][O:16][CH3:17])[s:13][c:14]1[C:31]([CH:28]1[CH2:27][CH2:26][N:25]([C:23]([O:22][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:24])[CH2:30][CH2:29]1)=[O:36]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-8eb0264670a949f0a490cdd34106cd52
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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