Methyl iodide → 5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[1-(cyclopropylmethoxy)butan-2-yl]-3-methylpiperidin-2-one
Reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:33][Si:34]([N-:35][Si:36]([CH3:37])([CH3:38])[CH3:39])([CH3:40])[CH3:41].[Cl:1][c:2]1[cH:3][c:4]([CH:8]2[CH2:9][CH2:10][C:11](=[O:30])[N:12]([CH:21]([CH2:22][O:23][CH2:24][CH:25]3[CH2:26][CH2:27]3)[CH2:28][CH3:29])[CH:13]2[c:14]2[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[cH:5][cH:6][cH:7]1.[I:31][CH3:32].[Li+:42]>>[Cl:1][c:2]1[cH:3][c:4]([CH:8]2[CH2:9][CH:10]([CH3:33])[C:11](=[O:30])[N:12]([CH:21]([CH2:22][O:23][CH2:24][CH:25]3[CH2:26][CH2:27]3)[CH2:28][CH3:29])[CH:13]2[c:14]2[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[cH:5][cH:6][cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-5458dbed4fcd49e7b142a3d853877c05
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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