Dimethylamine → N,N-dimethyl-2-{3-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]-1H-pyrazol-1-yl}acetamide

HRID 1565448Notes

Reaction equation

HRID 1565448 reaction equation
[CH2:82]([Cl:83])[Cl:84].[CH3:36][NH:37][CH3:38].[CH:66]([N:67]([CH2:68][CH3:69])[CH:70]([CH3:71])[CH3:72])([CH3:73])[CH3:74].[OH:75][C:76]([C:77]([F:78])([F:79])[F:80])=[O:81].[P-:39]([F:40])([F:41])([F:42])([F:43])([F:44])[F:45].[n:1]1[cH:2][cH:3][cH:4][c:5]2[cH:6][c:7]([C:11]3([c:14]4[cH:15][n:16][c:17]5[n:18]4[cH:19][c:20](-[c:23]4[n:24][n:25]([CH2:28][C:29]([O:31][C:30]([CH3:32])([CH3:33])[CH3:34])=[O:35])[cH:26][cH:27]4)[cH:21][n:22]5)[CH2:12][CH2:13]3)[cH:8][cH:9][c:10]12.[n:46]1([O:47][P+:48]([N:49]([CH3:50])[CH3:51])([N:52]([CH3:53])[CH3:54])[N:55]([CH3:56])[CH3:57])[c:58]2[cH:59][cH:60][cH:61][cH:62][c:63]2[n:64][n:65]1>>[n:1]1[cH:2][cH:3][cH:4][c:5]2[cH:6][c:7]([C:11]3([c:14]4[cH:15][n:16][c:17]5[n:18]4[cH:19][c:20](-[c:23]4[n:24][n:25]([CH2:28][C:29](=[O:31])[N:37]([CH3:36])[CH3:38])[cH:26][cH:27]4)[cH:21][n:22]5)[CH2:12][CH2:13]3)[cH:8][cH:9][c:10]12

Participants

8

Reactant 7

HCID 674DimethylamineHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 124335Benzotriazol-1-yloxy-tris(dimethylamino)phosphoniumHCID 67224711tert-butyl 3-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]-1H-pyrazol-1-ylacetate

Product 1

HCID 59421006N,N-dimethyl-2-{3-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]-1H-pyrazol-1-yl}acetamide

Sources & evidence

ORD record
ord-8fd7d702667641ddb41b67a3a2dc7b3f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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