Dimethylformamide → 2-Amino-5-chloro-3-phenylthiophene

HRID 1566307Notes

Reaction equation

HRID 1566307 reaction equation
[C:1]([O:2][C:3]([CH3:4])([CH3:5])[CH3:6])(=[O:7])[NH:8][c:9]1[s:10][c:11]([Cl:20])[cH:12][c:13]1-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[Cl:28][CH2:29][Cl:30].[O:31]=[CH:32][N:33]([CH3:34])[CH3:35].[OH:21][C:22]([C:23]([F:24])([F:25])[F:26])=[O:27]>>[NH2:8][c:9]1[s:10][c:11]([Cl:20])[cH:12][c:13]1-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 589117542-(N-Boc-amino)-5-chloro-3-phenyl-thiophene

Product 1

HCID 589118102-Amino-5-chloro-3-phenylthiophene

Sources & evidence

ORD record
ord-9d546f72396441e2b9ab741d4f222d0d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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