Tetrahydrofuran → 4-[1-(3-Bromo-4-methyl-thiophen-2-yl)-methanoyl]-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Br:9][c:10]1[cH:11][s:12][cH:13][c:14]1[CH3:15].[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH2:25][CH:26]([C:29]([N:30]([O:31][CH3:32])[CH3:33])=[O:34])[CH2:27][CH2:28]1.[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Li+:8].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[Br:9][c:10]1[c:11]([C:29]([CH:26]2[CH2:25][CH2:24][N:23]([C:21]([O:20][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:22])[CH2:28][CH2:27]2)=[O:34])[s:12][cH:13][c:14]1[CH3:15]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-8ed06ea26f824834a74dee81623f5c72
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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