Hydrochloric Acid → (4-{4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-ylamino]-2-methyl-phenoxy}-piperidin-1-yl)-(tetrahydro-furan-2-yl)-methanone

HRID 1569424Notes

Reaction equation

HRID 1569424 reaction equation
[CH3:10][O:11][CH2:12][CH2:13][O:14][c:15]1[cH:16][c:17]2[c:18]([NH:30][c:31]3[cH:32][c:33]([CH3:44])[c:34]([O:37][CH:38]4[CH2:39][CH2:40][NH:41][CH2:42][CH2:43]4)[cH:35][cH:36]3)[n:19][cH:20][n:21][c:22]2[cH:23][c:24]1[O:25][CH2:26][CH2:27][O:28][CH3:29].[CH3:45][N:46]([CH3:47])[CH:48]=[O:49].[ClH:9].[O:1]1[CH:2]([C:6](=[O:7])[OH:8])[CH2:3][CH2:4][CH2:5]1>>[O:1]1[CH:2]([C:6](=[O:8])[N:41]2[CH2:40][CH2:39][CH:38]([O:37][c:34]3[c:33]([CH3:44])[cH:32][c:31]([NH:30][c:18]4[c:17]5[cH:16][c:15]([O:14][CH2:13][CH2:12][O:11][CH3:10])[c:24]([O:25][CH2:26][CH2:27][O:28][CH3:29])[cH:23][c:22]5[n:21][cH:20][n:19]4)[cH:36][cH:35]3)[CH2:43][CH2:42]2)[CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 86079(+-)-Tetrahydro-2-furoic acidHCID 690519016,7-bis(2-methoxyethoxy)-N-(3-methyl-4-piperidin-4-yloxyphenyl)quinazolin-4-amine

Product 1

HCID 69054165(4-{4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-ylamino]-2-methyl-phenoxy}-piperidin-1-yl)-(tetrahydro-furan-2-yl)-methanone

Sources & evidence

ORD record
ord-7415fd54b80f46b09b5578a0e764433d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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