Dichloromethane → N-methyl-N-[2-methyl-5-(1-thia-3,8-diazaspiro[4.5]deca-2-en-2-yl)-4H-thieno[3,2-b]pyrrol-3-yl]thiophene-2-sulfonamide

HRID 1570605Notes

Reaction equation

[CH2:36]([c:38]1[cH:39][cH:40][cH:41][cH:42][cH:53]1)[S:43][C:44]1([CH2:50][NH:51][C:52](=[O:37])[c:54]2[cH:55][c:56]3[c:57]([nH:58]2)[c:59]([N:63]([S:64](=[O:65])(=[O:66])[c:67]2[s:68][cH:69][cH:70][cH:71]2)[CH3:72])[c:60]([CH3:62])[s:61]3)[CH2:45][CH2:46][NH:47][CH2:48][CH2:49]1.[Cl:73][CH2:74][Cl:75].[F:21][C:22]([S:23]([O:24][S:25]([C:26]([F:27])([F:28])[F:29])(=[O:30])=[O:31])(=[O:32])=[O:33])([F:34])[F:35].[c:1]1([P:2](=[O:3])([c:4]2[cH:5][cH:6][cH:7][cH:8][cH:9]2)[c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[cH:16][cH:17][cH:18][cH:19][cH:20]1>>[S:43]1[C:44]2([CH2:45][CH2:46][NH:47][CH2:48][CH2:49]2)[CH2:50][N:51]=[C:52]1[c:54]1[cH:55][c:56]2[c:57]([nH:58]1)[c:59]([N:63]([S:64](=[O:65])(=[O:66])[c:67]1[s:68][cH:69][cH:70][cH:71]1)[CH3:72])[c:60]([CH3:62])[s:61]2

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 13097Triphenylphosphine Oxide

HCID 67749Trifluoromethanesulfonic anhydride

HCID 59411373N-{[4-(benzylthio)piperidin-4-yl]methyl}-2-methyl-3-[methyl(2-thienylsulfonyl)amino]-4H-thieno[3,2-b]pyrrole-5-carboxamide

Product 1

HCID 59411372N-methyl-N-[2-methyl-5-(1-thia-3,8-diazaspiro[4.5]deca-2-en-2-yl)-4H-thieno[3,2-b]pyrrol-3-yl]thiophene-2-sulfonamide

Sources & evidence

ORD record: ord-fd5c732b17074b18a32f23033312d151
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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