Methane → 7-(Piperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester

HRID 1571355Notes

Reaction equation

HRID 1571355 reaction equation
[C:43].[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH2:12][CH2:13][CH:14]([CH2:17][O:18][c:19]2[cH:20][cH:21][c:22]3[c:27]([cH:28]2)[CH2:26][N:25]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:24][CH2:23]3)[CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:41][OH:42].[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1.[Pd:44]>>[NH:11]1[CH2:12][CH2:13][CH:14]([CH2:17][O:18][c:19]2[cH:20][cH:21][c:22]3[c:27]([cH:28]2)[CH2:26][N:25]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:24][CH2:23]3)[CH2:15][CH2:16]1

Participants

6

Reactant 5

HCID 297MethaneHCID 887MethanolHCID 8028TetrahydrofuranHCID 23938PalladiumHCID 112486364-(2-tert-Butoxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidine-1-carboxylic acid benzyl ester

Product 1

HCID 112794437-(Piperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-999a535e0fd34d5d91da04dd8b566279
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…