4-Methoxybenzylamine → {6,7-Dimethoxy-4-[(4-methoxy-benzylcarbamoyl)-methyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester

HRID 1571568Notes

Reaction equation

HRID 1571568 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][c:10]1[n:11][cH:12][c:13]([CH2:24][C:25](=[O:26])[OH:27])[c:14]2[cH:15][c:16]([O:22][CH3:23])[c:17]([O:20][CH3:21])[cH:18][c:19]12.[C:38]([P:39](=[O:40])([O:41][CH2:42][CH3:43])[O:44][CH2:45][CH3:46])#[N:47].[CH3:28][O:29][c:30]1[cH:31][cH:32][c:33]([CH2:34][NH2:35])[cH:36][cH:37]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][c:10]1[n:11][cH:12][c:13]([CH2:24][C:25](=[O:26])[NH:35][CH2:34][c:33]2[cH:32][cH:31][c:30]([O:29][CH3:28])[cH:37][cH:36]2)[c:14]2[cH:15][c:16]([O:22][CH3:23])[c:17]([O:20][CH3:21])[cH:18][c:19]12

Participants

4

Reactant 3

HCID 754524-MethoxybenzylamineHCID 76257Diethyl cyanophosphonateHCID 68613423[1-(Tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetic acid

Product 1

HCID 59341099{6,7-Dimethoxy-4-[(4-methoxy-benzylcarbamoyl)-methyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-3ddab94e05e9437f972afbe8d30f0bf7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…