Methyl iodide → 2-anilino-7-chloro-6-fluoro-5-methyl-1-phenyl-1,8-naphthyridin-4(1H)-one
Reaction equation
[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[CH3:11][N:12]([CH3:13])[CH2:14][CH2:15][N:16]([CH3:17])[CH3:18].[CH3:19][CH2:20][CH2:21][CH2:22][Li:23].[CH3:1][CH:2]1[CH2:3][CH2:4][CH2:5][N:6]([CH3:7])[C:8]1([CH3:9])[CH3:10].[CH3:50][I:51].[NH:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:31]1[n:32](-[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:33]2[n:34][c:35]([Cl:43])[c:36]([F:42])[cH:37][c:38]2[c:39](=[O:41])[cH:40]1>>[CH3:1][c:37]1[c:36]([F:42])[c:35]([Cl:43])[n:34][c:33]2[n:32](-[c:44]3[cH:45][cH:46][cH:47][cH:48][cH:49]3)[c:31]([NH:24][c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[cH:40][c:39](=[O:41])[c:38]21Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-0a7486edfa0a4c2fbfcbeb83a8b96a3b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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