Acetate → Ethyl 2-phenyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate

HRID 1572197Notes

Reaction equation

HRID 1572197 reaction equation
[C:27]([P:28]([C:29]([CH3:30])([CH3:31])[CH3:32])[c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1-[c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1)([CH3:45])([CH3:46])[CH3:47].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7]([C:12]([F:13])([F:14])[F:15])[n:8][c:9]([Br:11])[s:10]1.[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:62][CH2:63][O:64][CH2:65][CH3:66].[F-:25].[K+:26].[O-:54][C:55]([CH3:56])=[O:57].[O-:58][C:59]([CH3:60])=[O:61].[Pd+2:53].[c:16]1([B:22]([OH:23])[OH:24])[cH:17][cH:18][cH:19][cH:20][cH:21]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7]([C:12]([F:13])([F:14])[F:15])[n:8][c:9](-[c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[s:10]1

Participants

10

Reactant 9

HCID 175Acetate2×HCID 813Potassium CationHCID 3283Diethyl EtherHCID 8028TetrahydrofuranHCID 28179Fluoride IonHCID 66827Phenylboronic AcidHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27342152-(Di-tert-butylphosphino)biphenylHCID 132827592-Bromo-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester

Product 1

HCID 1483699Ethyl 2-phenyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate

Sources & evidence

ORD record
ord-e50459604f1940fbb7d3189c3aa2776f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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