Hydrochloric Acid → (RS)-6-Benzyloxy-2-[4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-ylmethyl]-3,4-dihydro-2H-naphthalen-1-one

HRID 1572730Notes

Reaction equation

HRID 1572730 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]2[c:16]([cH:17][cH:18]1)[C:15](=[O:19])[CH2:14][CH2:13][CH2:12]2.[CH3:21][c:22]1[cH:23][cH:24][c:25]([CH2:26][C:27]2([OH:33])[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]2)[cH:34][cH:35]1.[ClH:20].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]2[c:16]([cH:17][cH:18]1)[C:15](=[O:19])[CH:14]([CH2:37][N:30]1[CH2:29][CH2:28][C:27]([CH2:26][c:25]3[cH:24][cH:23][c:22]([CH3:21])[cH:35][cH:34]3)([OH:33])[CH2:32][CH2:31]1)[CH2:13][CH2:12]2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 105362424-(4-Methylbenzyl)-piperidin-4-olHCID 106822416-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one

Product 1

HCID 22628340(RS)-6-Benzyloxy-2-[4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-ylmethyl]-3,4-dihydro-2H-naphthalen-1-one

Sources & evidence

ORD record
ord-20e671bf5d42412cbcf7e21a113a9ee6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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