Trifluoroacetic acid → (4,4-Difluoro-piperidin-1-yl)-[1-(2-hydroxy-ethyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone

HRID 1573376Notes

Reaction equation

HRID 1573376 reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH2:7][CH2:8][n:9]1[c:10]([C:28](=[O:29])[N:30]2[CH2:31][CH2:32][C:33]([F:36])([F:37])[CH2:34][CH2:35]2)[cH:11][c:12]2[c:13]1[n:14][cH:15][c:16]([O:18][CH:19]1[CH2:20][CH2:21][N:22]([CH:25]([CH3:26])[CH3:27])[CH2:23][CH2:24]1)[cH:17]2)([CH3:5])([CH3:38])[CH3:39].[OH:40][C:41]([C:42]([F:43])([F:44])[F:45])=[O:46]>>[OH:6][CH2:7][CH2:8][n:9]1[c:10]([C:28](=[O:29])[N:30]2[CH2:31][CH2:32][C:33]([F:36])([F:37])[CH2:34][CH2:35]2)[cH:11][c:12]2[c:13]1[n:14][cH:15][c:16]([O:18][CH:19]1[CH2:20][CH2:21][N:22]([CH:25]([CH3:26])[CH3:27])[CH2:23][CH2:24]1)[cH:17]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68423931[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone

Product 1

HCID 16727146(4,4-Difluoro-piperidin-1-yl)-[1-(2-hydroxy-ethyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone

Sources & evidence

ORD record
ord-e8bd86dfb7e1405ebae4880e9a29f469
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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