Sodium ion → 2-(4-Chloro-phenyl)-5-{4-[2-(2,2-dimethyl-morpholin-4-yl)-ethoxy]-3-methoxy-phenyl}-5H-thiazolo[5,4-c]pyridin-4-one

HRID 1573977Notes

Reaction equation

HRID 1573977 reaction equation
[CH2:80]1[O:81][CH2:82][CH2:83][CH2:84]1.[CH3:1][C:2]1([CH3:11])[O:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][OH:10])[CH2:7]1.[Cl:12][c:13]1[cH:14][cH:15][c:16](-[c:19]2[s:20][c:21]3[c:22](=[O:37])[n:23](-[c:28]4[cH:29][c:30]([O:35][CH3:36])[c:31]([OH:34])[cH:32][cH:33]4)[cH:24][cH:25][c:26]3[n:27]2)[cH:17][cH:18]1.[Cl:85][CH2:86][Cl:87].[Na+:72].[O:57]=[C:58]([O:59][CH:60]([CH3:61])[CH3:62])[N:63]=[N:64][C:65]([O:66][CH:67]([CH3:68])[CH3:69])=[O:70].[OH-:71].[OH:73][c:74]1[cH:75][cH:76][cH:77][cH:78][cH:79]1.[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1>>[CH3:1][C:2]1([CH3:11])[O:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][O:10][c:31]2[c:30]([O:35][CH3:36])[cH:29][c:28](-[n:23]3[c:22](=[O:37])[c:21]4[s:20][c:19](-[c:16]5[cH:15][cH:14][c:13]([Cl:12])[cH:18][cH:17]5)[n:27][c:26]4[cH:25][cH:24]3)[cH:33][cH:32]2)[CH2:7]1

Participants

10

Reactant 9

HCID 923Sodium ionHCID 961HydroxideHCID 996PhenolHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 129508532-(2,2-Dimethylmorpholino)ethanolHCID 575017652-(4-Chloro-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-5H-thiazolo[5,4-c]pyridin-4-one

Product 1

HCID 117067532-(4-Chloro-phenyl)-5-{4-[2-(2,2-dimethyl-morpholin-4-yl)-ethoxy]-3-methoxy-phenyl}-5H-thiazolo[5,4-c]pyridin-4-one

Sources & evidence

ORD record
ord-ab20118157494dc198f485b8fb622672
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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