Dimethylformamide → [2-[[1-(4-bromo-2,6-dimethylphenyl)-3,5-diethylpyrazol-4-yl]methyl]-3,4-dihydro-1H-isoquinolin-3-yl]methanol

HRID 1574434Notes

Reaction equation

HRID 1574434 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:20])[c:5](-[n:9]2[n:10][c:11]([CH2:18][CH3:19])[c:12]([CH2:16][OH:17])[c:13]2[CH2:14][CH3:15])[c:6]([CH3:8])[cH:7]1.[CH2:28]([Cl:29])[Cl:30].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[CH3:43][N:44]([CH3:45])[CH:46]=[O:47].[OH:31][CH2:32][CH:33]1[NH:34][CH2:35][c:36]2[cH:37][cH:38][cH:39][cH:40][c:41]2[CH2:42]1>>[Br:1][c:2]1[cH:3][c:4]([CH3:20])[c:5](-[n:9]2[n:10][c:11]([CH2:18][CH3:19])[c:12]([CH2:16][N:34]3[CH:33]([CH2:32][OH:31])[CH2:42][c:41]4[c:36]([cH:37][cH:38][cH:39][cH:40]4)[CH2:35]3)[c:13]2[CH2:14][CH3:15])[c:6]([CH3:8])[cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 3752277(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanolHCID 218373201-(4-bromo-2,6-dimethylphenyl)-3,5-diethyl-1H-pyrazol-4-yl-methanol

Product 1

HCID 67553306[2-[[1-(4-bromo-2,6-dimethylphenyl)-3,5-diethylpyrazol-4-yl]methyl]-3,4-dihydro-1H-isoquinolin-3-yl]methanol

Sources & evidence

ORD record
ord-f242a833648d413b9d30ed2b8a42e263
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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