Tetrahydrofuran → 5-Fluoro-8-methoxychromane

HRID 1575718Notes

Reaction equation

HRID 1575718 reaction equation
[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[F:1][c:2]1[c:3]([CH2:11][CH2:12][CH2:13][OH:14])[c:4]([OH:10])[c:5]([O:8][CH3:9])[cH:6][cH:7]1.[O:34]=[C:35]([O:36][CH:37]([CH3:38])[CH3:39])[N:40]=[N:41][C:42]([O:43][CH:44]([CH3:45])[CH3:46])=[O:47].[c:15]1([P:16]([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[cH:29][cH:30][cH:31][cH:32][cH:33]1>>[F:1][c:2]1[c:3]2[c:4]([c:5]([O:8][CH3:9])[cH:6][cH:7]1)[O:14][CH2:13][CH2:12][CH2:11]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 595119113-Fluoro-2-(3-hydroxypropyl)-6-methoxyphenol

Product 1

HCID 595118145-Fluoro-8-methoxychromane

Sources & evidence

ORD record
ord-c48705618ff14d0e993aca8eb9188f92
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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