4-Aminopyridine → 5044-41-7

HRID 1576276Notes

Reaction equation

HRID 1576276 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.CO[CH:10]1[CH2:14][CH2:13][CH:12](OC)O1>C(O)(=O)C>[N:5]1[CH:6]=[CH:7][C:2]([N:1]2[CH:10]=[CH:14][CH:13]=[CH:12]2)=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 17274-AminopyridineHCID 790982,5-Dimethoxytetrahydrofuran

Product 1

HCID 8200945044-41-7

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 1-liter 3-neck flask equipped with stirrer, condenser, heating mantle, addition funnel and thermometer is charged with 47 g (0.5 mole) of 4-aminopyridine and 66 g (0.5 mole) of 2,5-dimethoxytetrahydrofuran. These materials are mixed together and 210 ml of glacial acetic acid is added dropwise with stirring over ten minutes while maintaining the temperature at less than 20°C.

Workup

  1. customA 1-liter 3-neck flask equipped with stirrer, condenser
  2. temperatureheating
  3. additionmantle, addition funnel and thermometer
  4. additionThese materials are mixed together
  5. temperaturewhile maintaining the temperature at less than 20°C.

Sources & evidence

ORD record
ord-b5e3202ffcfc4b8e83d6dbc7ed0e25a0
Source dataset
uspto-grants-1976_09
Patent number
US03980089

Reaction notes

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