p-Toluenesulfonic acid → HCID 54347004, compound

HRID 1576417Notes

Reaction equation

HRID 1576417 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](O)([CH3:19])[CH2:15][C:16]([OH:18])=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([CH3:19])=[CH:15][C:16]([OH:18])=[O:17])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 21512627HCID 21512627, compound

Product 1

HCID 54347004HCID 54347004, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 105.5 g 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutyric acid and 5.3 g p-toluenesulfonic acid in 1500 ml of toluene is heated for 2,5 hours and worked up in the usual manner to give 3-(4'-fluoro-4-biphenylyl)-2-butenoic acid, m.p. 58° - 60°.

Sources & evidence

ORD record
ord-288e20695f7e45bc87e2cb0298d33a09
Source dataset
uspto-grants-1976_09
Patent number
US03980795

Reaction notes

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