Hydrogen Peroxide → HCID 131710455, compound

HRID 1576743Notes

Reaction equation

HRID 1576743 reaction equation
[ClH:1].[Cl:2][C:3]1[C:9](=[O:10])[N:8]([CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[S:5][C:4]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[OH:31]O>C(O)(=O)C>[ClH:2].[ClH:1].[Cl:2][C:3]1[C:9](=[O:10])[N:8]([CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]2)[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[S:5](=[O:31])[C:4]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 131710456HCID 131710456, compound

Product 1

HCID 131710455HCID 131710455, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3-Chloro-5-[3-(4-methyl-1-piperazinyl)propyl]-2-phenyl-1,5-benzothiazepin-4(5H)-one, hydrochloride (prepared as described in Example 1) is treated with one equivalent of hydrogen peroxide in dilute acetic acid, and allowed to stand for about 16 hours. Solvent removal yields the title compound.

Workup

  1. customSolvent removal

Sources & evidence

ORD record
ord-75bb68ad271f41cca3de9259a9eb0496
Source dataset
uspto-grants-1976_09
Patent number
US03983106

Reaction notes

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