Ethanolamine → alpha-[[(2-Hydroxyethyl)amino]methyl]benzyl alcohol

HRID 1576796Notes

Reaction equation

HRID 1576796 reaction equation
[CH2:1]1[O:9][CH:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:10]([CH2:12][NH2:13])[OH:11]>O>[OH:9][CH:2]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)[CH2:1][NH:13][CH2:12][CH2:10][OH:11]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 7276Styrene Oxide

Product 1

HCID 107278alpha-[[(2-Hydroxyethyl)amino]methyl]benzyl alcoholYield 30.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Styrene oxide (1.2 g.), ethanolamine (0.6 g.) and water (0.05 g.) were heated at 70° with stirring for 24 hours. The mixture was cooled, evacuated and the oil formed triturated with ether to give title compound (550 mg.) m.p 93.5° - 95°.

Workup

  1. temperatureThe mixture was cooled
  2. customevacuated
  3. customthe oil formed
  4. customtriturated with ether

Sources & evidence

ORD record
ord-54578ca95f734989914b412731aed45e
Source dataset
uspto-grants-1976_09
Patent number
US03983111

Reaction notes

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