Sodium Hydroxide → 2-Phenylmorpholine

HRID 1576797Notes

Reaction equation

HRID 1576797 reaction equation
O[CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][NH:4][CH2:5][CH2:6][OH:7].[OH-].[Na+]>Cl>[C:8]1([CH:2]2[O:7][CH2:6][CH2:5][NH:4][CH2:3]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 107278alpha-[[(2-Hydroxyethyl)amino]methyl]benzyl alcohol

Product 1

HCID 911012-Phenylmorpholine

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

N-(2'-hydroxy-2'-phenylethyl)-ethanolamine (5.3 g.) was dissolved in 6N hydrochloric acid (100 ml.) and the solution heated at 110° for 4 hours. The mixture was basified with sodium hydroxide solution and extracted into ether. The extract was washed with water, dried over anhydrous sodium sulphate and evaporated to give a crude sample of title compound (Ig.) as an orange oil.

Workup

  1. temperaturethe solution heated at 110° for 4 hours
  2. extractionextracted into ether
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous sodium sulphate
  5. customevaporated

Sources & evidence

ORD record
ord-bf144086edc844319fcbfdcb38de581a
Source dataset
uspto-grants-1976_09
Patent number
US03983111

Reaction notes

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