反应详情

A mixture of 5.3 parts of N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]thiourea, 6 parts of iodomethane, 5 parts of acetic acid and 90 parts of ethyl acetate is stirred for 2 days at room temperature. Upon the addition of 2,2'-oxybispropane, the product is crystallized. It is filtered off and dried, yielding 6 parts (80%) of methyl N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]carbamimidothioate monohydroiodide.

1. customthe product is crystallized
2. filtrationIt is filtered off
3. customdried