Hydrochloric Acid → HCID 12952783, compound

HRID 1577117Notes

Reaction equation

HRID 1577117 reaction equation
[CH3:1][O:2][CH:3](OC)[CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[S:7].Cl.C(=O)([O-])O.[Na+]>>[CH3:1][O:2][CH:3]1[S:7][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[N:5][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 12952797HCID 12952797, compound

Product 1

HCID 12952783HCID 12952783, compoundYield 73%

Procedure

A mixture of 6 parts of N-(2,2-dimethoxyethyl)-4-(4-hydroxyphenyl)-1-piperazinecarbothioamide and 25 parts of a diluted hydrochloric acid solution is stirred overnight at room temperature. Upon the addition of sodium hydrogen carbonate, the product is allowed to crystallize. It is filtered off and recrystallized from ethanol, yielding 4.3 parts (73%) of 4-[4-(4,5-dihydro-5-methoxy-2-thiazolyl)-1-piperazinyl]phenol; mp. 165.6° C.

Workup

  1. customto crystallize
  2. filtrationIt is filtered off
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-ca871ba5fbd3449b851b34e37d0bbe74
Source dataset
uspto-grants-1981_09
Patent number
US04287195

Reaction notes

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