反应详情

4-Amino-2,6-dichloro-7,8-dimethoxyquinazoline (4.9 g.), 4-(2-ethoxyethoxy)piperidine (3.2 g.) and triethylamine (10 ml.) in n-butanol (400 ml.) are heated at reflux overnight under an atmosphere of nitrogen. The mixture is then cooled, evaporated in vacuo, and the residue basified (aqueous Na2CO3) and extracted 3 times with chloroform. The combined chloroform extracts are evaporated and the residue chromatographed on neutral alumina to give the crude product which is converted to the hydrochloride salt by treatment with hydrogen chloride in ethanol to afford the title compound.

1. temperatureat reflux overnight under an atmosphere of nitrogen
2. temperatureThe mixture is then cooled
3. customevaporated in vacuo
4. extractionextracted 3 times with chloroform
5. customThe combined chloroform extracts are evaporated
6. customthe residue chromatographed on neutral alumina
7. customto give the crude product which