Hydrochloric Acid → HCID 20569941, compound

HRID 1577811Notes

Reaction equation

HRID 1577811 reaction equation
C([O:3][C:4](=O)[C:5]([CH3:22])=[CH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)=O)C.O.[NH2:25][NH2:26].Cl>O>[CH3:22][C:5]1[C:4](=[O:3])[NH:25][N:26]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 54186407HCID 54186407, compound

Product 1

HCID 20569941HCID 20569941, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 31.2 g of 2-methyl-4-(4'-fluoro-4-biphenylyl)-4-oxo-2-butenoic acid ethyl ester, 60 ml of 24% aqueous hydrazine hydrate solution and 50 ml of water is boiled for one hour. When it has cooled, 25 ml of concentrated hydrochloric acid is added and the liquid is boiled for an additional 30 minutes. After again cooling the mixture, the 4-methyl-6-(4'-fluoro-4-biphenylyl)-2,3-dihydropyridazin-3-one obtained is filtered off and washed with water. m.p. 247°-248°.

Workup

  1. temperatureWhen it has cooled
  2. waitthe liquid is boiled for an additional 30 minutes
  3. temperatureAfter again cooling the mixture

Sources & evidence

ORD record
ord-9df195aad4a34390b0975544e77cf73e
Source dataset
uspto-grants-1981_09
Patent number
US04289774

Reaction notes

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