Cysteamine Hydrochloride → 2-(4-Bromophenyl)-1,3-thiazolidine

HRID 1577814Notes

Reaction equation

HRID 1577814 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.Cl.[NH2:11][CH2:12][CH2:13][SH:14]>C(N(CC)CC)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]2[NH:11][CH2:12][CH2:13][S:14]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 707414-Bromobenzaldehyde

Product 1

HCID 27710642-(4-Bromophenyl)-1,3-thiazolidine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure of Example 1 was repeated, except that the reactants consisted of 18.5 g. of 4-bromobenzaldehyde and 27 g. of 2-aminoethanethiol hydrochloride, and the reaction mixture also contained 10 ml. of triethylamine. Since removal of solvent left a solid residue, the material was recrystallized from benzene/hexane to give 2-(4-bromophenyl)thiazolidine, m.p. 105°-7°. The following elemental analysis was obtained:

Workup

  1. customSince removal of solvent
  2. waitleft a solid residue
  3. customthe material was recrystallized from benzene/hexane

Sources & evidence

ORD record
ord-1d70d3d5ba834942b2e431e7f6bb1991
Source dataset
uspto-grants-1981_09
Patent number
US04289766

Reaction notes

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