Triethylamine → 4-(Butylsulfamoyl)phenyl 2-methylprop-2-enoate
Reaction equation
[C:1](Cl)(=[O:5])[C:2]([CH3:4])=[CH2:3].[CH2:7]([NH:11][S:12]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH2:8][CH2:9][CH3:10].C(N(CC)CC)C>C(Cl)Cl>[CH2:7]([NH:11][S:12]([C:15]1[CH:16]=[CH:17][C:18]([O:21][C:1](=[O:5])[C:2]([CH3:4])=[CH2:3])=[CH:19][CH:20]=1)(=[O:14])=[O:13])[CH2:8][CH2:9][CH3:10]Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A solution of 20.91 g (0.20 mol) of methacryloyl chloride in 80 ml of methylene chloride was added to a solution of 45.86 g (0.20 mol) of N-butyl-4-hydroxybenzenesulfonamide, 20.24 g (0.20 mol) of triethylamine and 320 ml of methylene chloride and cooled to 0° C. over a period of approximately 20 minutes. The mixture was then stirred for another 1.5 hours with cooling, washed three times with water, dried over magnesium sulfate and concentrated in vacuo in a warm bath. The resultant oil (Note 1) was cooled and crystallized to an oily solid. Removal of residual solvent with high vacuum caused this material to completely solidify. This solid was recrystallized from 600 ml of cyclohexane with filtering. Collection of the white solid and drying at room temperature in vacuo gave 38.9 g of N-butyl-4-methacryloyloxybenzenesulfonamide; m.p.=59° to 60° C.
Workup
- temperaturewith cooling
- washwashed three times with water
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo in a warm bath
- temperatureThe resultant oil (Note 1) was cooled
- customcrystallized to an oily solid
- customRemoval of residual solvent with high vacuum
- customThis solid was recrystallized from 600 ml of cyclohexane
- filtrationwith filtering
- customCollection of the white solid
- customdrying at room temperature in vacuo
Sources & evidence
- ORD record
- ord-f8150e249ad545678f0effdd8b94cf1b
- Source dataset
- uspto-grants-1981_09
- Patent number
- US04289865
Reaction notes
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