Hydrazine hydrate (1:1) → HCID 131712424, compound

HRID 1578161Notes

Reaction equation

HRID 1578161 reaction equation
[OH2:1].[NH2:2][NH2:3].[NH:4]([C:69]([O:71][CH2:72][C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)=[O:70])[C@@H:5]([C:13]([NH:15][C@H:16]([C:27]([NH:29][C@H:30]([C:35]([NH:37][C@H:38]([C:43]([NH:45][C@H:46]([C:54]([NH:56][C@H:57]([C:65](OC)=[O:66])[CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:55])[CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)=[O:44])[CH2:39][C:40](=[O:42])[NH2:41])=[O:36])[CH2:31][CH2:32][CH2:33][CH3:34])=[O:28])[CH2:17][S:18][CH2:19][C:20]1[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=1)=O)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CN(C)C=O>[NH:4]([C:69]([O:71][CH2:72][C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)=[O:70])[C@@H:5]([C:13]([NH:15][C@H:16]([C:27]([NH:29][C@H:30]([C:35]([NH:37][C@H:38]([C:43]([NH:45][C@H:46]([C:54]([NH:56][C@H:57]([C:65]([NH:2][NH2:3])=[O:66])[CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:55])[CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)=[O:44])[CH2:39][C:40](=[O:42])[NH2:41])=[O:36])[CH2:31][CH2:32][CH2:33][CH3:34])=[O:28])[CH2:17][S:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([CH3:24])=[CH:25][CH:26]=1)=[O:1])[CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 131712425HCID 131712425, compound

Product 1

HCID 131712424HCID 131712424, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5 ml of hydrazine-hydrate are added to 5 g of Z-(D)Phe-Cys(MBzl)-Nle-Asn-Phe-Phe-OMe in 80 ml dimethylformamide and the mixture allowed to stand for 2 days at room temperature. The title compound is obtained after precipitation with methanol, filtration, washing with methanol and drying: [α]D20 =-32° (c=1.0 in dimethylformamide); decomposition at 248° C.

Sources & evidence

ORD record
ord-7a04378d05a5405ba95d83281475b8e9
Source dataset
uspto-grants-1981_09
Patent number
US04291022

Reaction notes

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