Propylamine → HCID 21559905, compound

HRID 1578372Notes

Reaction equation

HRID 1578372 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:11][C:12]1[CH:21]=[CH:20][C:17]([O:18][CH3:19])=[C:14]([O:15][CH3:16])[CH:13]=1.[CH2:22]([NH2:25])[CH2:23][CH3:24]>CCO>[CH2:22]([NH:25][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:11][C:12]1[CH:21]=[CH:20][C:17]([O:18][CH3:19])=[C:14]([O:15][CH3:16])[CH:13]=1)[CH2:23][CH3:24]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 21559907HCID 21559907, compound

Product 1

HCID 21559905HCID 21559905, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A reaction mixture containing 5.14 g (16.8 mmol) of 6-chloro-9-veratrylpurine, 7.0 ml (84.9 mmol) of propylamine and 60 ml of EtOH was refluxed for 2.5 hrs. Evaporation of the reaction mixture gave a residual solid which was recrystallized from acetone to give the crude product; yield 4.78 g (87.0%) mp 117°-120°. Further recrystallizations of the crude white material from acetone gave the analytical material; mp 122°-125°.

Workup

  1. temperaturewas refluxed for 2.5 hrs
  2. customEvaporation of the reaction mixture
  3. customgave a residual solid which
  4. customwas recrystallized from acetone

Sources & evidence

ORD record
ord-0c85a2af9e564a7c9984c6539aaa21ac
Source dataset
uspto-grants-1976_02
Patent number
US03936454

Reaction notes

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