Tetrahydrofuran → 5-Methoxy-2-(1H-pyrrol-1-yl)aniline

HRID 1578697Notes

Reaction equation

HRID 1578697 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][CH:11]=[CH:10]2)=[C:5]([N+:14]([O-])=O)[CH:4]=1.O1CCCC1>O>[NH2:14][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[N:9]1[CH:10]=[CH:11][CH:12]=[CH:13]1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 2803813HCID 2803813, compound

Product 1

HCID 27644155-Methoxy-2-(1H-pyrrol-1-yl)aniline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred solution of 33.5 g (0.154 mole) of 1-(4-methoxy-2-nitrophenyl)pyrrole in 684 ml. of tetrahydrofuran and 340 ml. of water is treated according to the manipulative procedure described in Example 13(b) to give 1-(2-amino-4-methoxyphenyl)pyrrole, m.p. 42°-43° C.

Sources & evidence

ORD record
ord-39bf1a8469694c76aabc614a106c8ceb
Source dataset
uspto-grants-1976_02
Patent number
US03939159

Reaction notes

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