反应详情

4-Chloro-7-nitro-2,5-bis(trifluoromethyl)benzimidazole (2.2 grams), propylamine (0.39 gram), and excess triethylamine were mixed in about 50 milliliters of ethanol. The reaction mixture was heated to reflux and refluxed over a weekend (about 60 hours). The reaction mixture was then poured into water and acidified. The desired 4-propylamino-7-nitro-2,5-bis(trifluoromethyl)benzimidazole product precipitated and was separated by filtration. After recrystallization from a mixture of ethanol and water, the compound melted at 129°-31°C. Analysis, Calc.: C, 40.4; H, 2.81; N, 15.73 Found: C, 40.5; H, 2.78; N, 15.51

1. temperatureThe reaction mixture was heated
2. temperatureto reflux
3. temperaturerefluxed over a weekend (about 60 hours)
4. customThe desired 4-propylamino-7-nitro-2,5-bis(trifluoromethyl)benzimidazole product precipitated
5. customwas separated by filtration
6. customAfter recrystallization
7. additionfrom a mixture of ethanol and water