Hydrochloric Acid → HCID 53907760, compound

HRID 1578853Notes

Reaction equation

HRID 1578853 reaction equation
[O:1]([C:8]1[C:16]([S:17](=[O:30])(=[O:29])[NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[NH:25]C(=O)C)=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[NH:31][CH2:32][C:33]1[O:37][CH:36]=[CH:35][CH:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>[OH-].[Na+]>[O:1]([C:8]1[C:16]([S:17](=[O:30])(=[O:29])[NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[NH2:25])=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[NH:31][CH2:32][C:33]1[O:37][CH:36]=[CH:35][CH:34]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54430759HCID 54430759, compound

Product 1

HCID 53907760HCID 53907760, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The mixture of 3 g of 4-phenoxy-3-furfurylamino-5-(2-acetamidophenylsulfamoyl)-benzoic acid and 30 ml of 2N aqueous sodium hydroxide is refluxed for 4 1/2 hours. After cooling to room temperature it is acidified with hydrochloric acid to pH = 2. The precipitate formed is filtered off and recrystallized from aqueous ethanol, to yield the 4-phenoxy-3-furfurylamino-5-(2-aminophenylsulfamoyl)-benzoic acid melting at 105°-110° with decomposition.

Workup

  1. temperatureis refluxed for 4 1/2 hours
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-ca8ebe39c73b440280d0d664052adf2c
Source dataset
uspto-grants-1976_02
Patent number
US03939267

Reaction notes

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