Formaldehyde → HCID 21557474, compound

HRID 1579008Notes

Reaction equation

HRID 1579008 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[CH2:13]=O.[CH:15]1[CH:16]=[C:17]2[C:22]3=[C:23]([C:25]([NH:27][C:28](=[O:29])[C:21]3=[CH:20][CH:19]=[CH:18]2)=[O:26])[CH:24]=1>CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][N:10]([CH2:13][N:27]2[C:28](=[O:29])[C:21]3[CH:20]=[CH:19][CH:18]=[C:17]4[C:22]=3[C:23](=[CH:24][CH:15]=[CH:16]4)[C:25]2=[O:26])[CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 66491NaphthalimideHCID 944591-(2-Pyridyl)piperazine

Product 1

HCID 21557474HCID 21557474, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

An equimolar mixture of 1-(2-pyridinyl)piperazine, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]1H-benz[de]isoquinoline-1,3(2H)-dione.

Workup

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

Sources & evidence

ORD record
ord-5cec333486b9431e849210c9dbe634d5
Source dataset
uspto-grants-1976_02
Patent number
US03940398

Reaction notes

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