Formaldehyde → HCID 21557468, compound

HRID 1579020Notes

Reaction equation

HRID 1579020 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:13]=O.[CH:15]1[CH:16]=[C:17]2[C:22]3=[C:23]([C:25]([NH:27][C:28](=[O:29])[C:21]3=[CH:20][CH:19]=[CH:18]2)=[O:26])[CH:24]=1>CN(C)C=O>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][N:27]3[C:28](=[O:29])[C:21]4[CH:20]=[CH:19][CH:18]=[C:17]5[C:22]=4[C:23](=[CH:24][CH:15]=[CH:16]5)[C:25]3=[O:26])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 70961-PhenylpiperazineHCID 66491Naphthalimide

Product 1

HCID 21557468HCID 21557468, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

An equimolar mixture of N-phenylpiperazine, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield 2-[(4-phenyl-1-piperazinyl)methyl]-1H-benz[de]isoquinoline-1,3(2H)-dione.

Workup

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

Sources & evidence

ORD record
ord-09871f29275f47919ad7340225c337a3
Source dataset
uspto-grants-1976_02
Patent number
US03940397

Reaction notes

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