Hydrochloric Acid → HCID 12291086, compound

HRID 1579064Notes

Reaction equation

HRID 1579064 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:13]3[N:12]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:11]=[C:10]([C:20]([O:22]C)=[O:21])[C:9]=3[CH2:8][CH2:7][C:6]=2[CH:24]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:13]3[N:12]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:11]=[C:10]([C:20]([OH:22])=[O:21])[C:9]=3[CH2:8][CH2:7][C:6]=2[CH:24]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12291071HCID 12291071, compound

Product 1

HCID 12291086HCID 12291086, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 15 parts of methyl 7-chloro-1-phenyl-4,5-dihydro-1H-benz[g]indazole-3-carboxylate, 100 parts of aqueous 10 percent sodium hydroxide solution and 120 parts of methanol is refluxed and stirred for 3 hours. The mixture is then cooled and acidified with concentrated hydrochloric acid. The solid which forms is separated by filtration, washed with water, and dried to give 7-chloro-1-phenyl-4,5-dihydro-1H-benz[g]indazole-3-carboxylic acid melting at about 282°C. with evolution of gas.

Workup

  1. temperatureis refluxed
  2. temperatureThe mixture is then cooled
  3. customThe solid which forms is separated by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-1994a9fa05674274bc5ecc4fd1f922f0
Source dataset
uspto-grants-1976_02
Patent number
US03940418

Reaction notes

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