反应详情

A stirred mixture of 3-chloro-4-fluorobenzaldehyde (55 g, 0.35 mole), malonic acid (47 g, 0.45 mole) and 3.5 ml of piperidine in 138 ml of pyridine was heated on a steam bath for 2 hours. The reaction solution was poured into a mixture of 200 ml of concentrated hydrochloric acid and 320 g of ice to give after filtration and water wash 44 g (63%). The crude intermediate was used without further purification in part D.

1. temperaturewas heated on a steam bath for 2 hours
2. customto give
3. filtrationafter filtration and water
4. washwash 44 g (63%)
5. customThe crude intermediate was used without further purification in part D