反应详情

A mixture of 2.0 g. (0.005 mole) of 4,5-dihydro-3-(4-hydroxy-3-methoxycarbonylphenyl)2-phenylbenz[e]indole, 75 ml. of ammonium hydroxide, and 40 ml. of dimethyl formamide was heated under reflux for 3 hours, cooled, diluted with water, acidified, and extracted with ether. The ether phase was dried over sodium sulfate and concentrated to a solid. Recrystallization from benzene gave 1.21 g. (63%) of colorless crystals, m.p. 213°-215°.

1. additionA mixture of 2.0 g
2. temperatureunder reflux for 3 hours
3. temperaturecooled
4. extractionextracted with ether
5. dry with materialThe ether phase was dried over sodium sulfate
6. concentrationconcentrated to a solid
7. customRecrystallization from benzene
8. customgave 1.21 g