Potassium Carbonate → HCID 21565109, compound

HRID 1580110Notes

Reaction equation

HRID 1580110 reaction equation
[CH:1]([C:3]1[CH:12]=[CH:11][C:10]([N:13]([CH3:15])[CH3:14])=[CH:9][C:4]=1[O:5][CH2:6][C:7]#[N:8])=O.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[CH3:14][N:13]([CH3:15])[C:10]1[CH:11]=[CH:12][C:3]2[CH:1]=[C:6]([C:7]#[N:8])[O:5][C:4]=2[CH:9]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 54476035HCID 54476035, compound

Product 1

HCID 21565109HCID 21565109, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

15.3 parts of the nitrile is dissolved in 100 parts by volume of dimethylformamide and stirred with 10 parts of potassium carbonate for 15 hours at 70°C. The whole is then diluted with 1,000 parts of water, filtered by suction and the filter residue is dried. For further purification it is sublimed at 80°C and 1 mm and the sublimate is recrystallized from methylcyclohexane. The 6-dimethylaminobenzofuran-2-carbonitrile is obtained in the form of colorless crystals having a melting point of 70° to 71°C which dissolve in benzene with an intense blue-violet fluorescence.

Workup

  1. filtrationfiltered by suction
  2. customthe filter residue is dried
  3. customFor further purification it
  4. customis sublimed at 80°C
  5. custom1 mm and the sublimate is recrystallized from methylcyclohexane

Sources & evidence

ORD record
ord-0e158280b6ef485f855f0e0ca330ae56
Source dataset
uspto-grants-1976_01
Patent number
US03932446

Reaction notes

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